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Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.

ABSTRACT: Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC₅₀ values of 1.58 and 3.87 μM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 μM.

SUBMITTER: Nian Y

PROVIDER: S-EPMC9078504 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.

Nian Yin Y Lu Ni-Hong NH Liu Xiao-Ling XL Li Da-Shan DS Zhou Lin L Qiu Ming-Hua MH

RSC advances 20180219 14

Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1. ...[more]

PMID: 35539105

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