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Iridium-catalysed direct sulfamidation of quinazolinones.

ABSTRACT: Ir-catalysed direct sulfamidation of quinazolinones has been achieved. A series of ortho-diamided quinazolinones were obtained in up to 96% yields. This transformation could proceed smoothly with a low catalyst loading under mild conditions with nitrogen released as the sole byproduct. This approach potentially provides an environmentally benign sulfamidation process for atom/step economic syntheses of useful pharmaceutical molecules or important building blocks.

SUBMITTER: Feng Y

PROVIDER: S-EPMC9078565 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Iridium-catalysed direct sulfamidation of quinazolinones.

Feng Yadong Y Li Yudong Y Yu Yunliang Y Wang Lianhui L Cui Xiuling X

RSC advances 20180223 16

Ir-catalysed direct sulfamidation of quinazolinones has been achieved. A series of <i>ortho</i>-diamided quinazolinones were obtained in up to 96% yields. This transformation could proceed smoothly with a low catalyst loading under mild conditions with nitrogen released as the sole byproduct. This approach potentially provides an environmentally benign sulfamidation process for atom/step economic syntheses of useful pharmaceutical molecules or important building blocks. ...[more]

PMID: 35539849

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