Fragmentation of Stones by Burst Wave Lithotripsy in the First 19 Humans.

ABSTRACT:

Purpose

We report stone comminution in the first 19 human subjects by burst wave lithotripsy (BWL), which is the transcutaneous application of focused, cyclic ultrasound pulses.

Materials and methods

This was a prospective multi-institutional feasibility study recruiting subjects undergoing clinical ureteroscopy (URS) for at least 1 stone ≤12 mm as measured on computerized tomography. During the planned URS, either before or after ureteroscope insertion, BWL was administered with a handheld transducer, and any stone fragmentation and tissue injury were observed. Up to 3 stones per subject were targeted, each for a maximum of 10 minutes. The primary effectiveness outcome was the volume percent comminution of the stone into fragments ≤2 mm. The primary safety outcome was the i

SUBMITTER: Harper JD 

PROVIDER: S-EPMC9078634 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature