Accelerated fabrication of antibacterial and osteoinductive electrospun fibrous scaffolds via electrochemical deposition.

ABSTRACT: Electrospun fibrous scaffolds have attracted much research interest due to their many applications in orthopedics and other relevant fields. However, poor surface bioactivity of the polymer scaffold body significantly limits the implementation of many potential applications, and an effective solution remains a great challenge for researchers. Herein, a highly efficient method, namely pulsed electrochemical deposition (ED) with co-electrospinning nano-Ag dopant, to fabricate poly(l-lactic acid) (PLLA)/nano-Ag composite fibers is presented. The resulting product demonstrated excellent antibacterial properties, as well as strong capabilities in facilitating the precipitation of calcium phosphate crystals at fiber surfaces and in promoting osteogenic differentiation. In the process of ED, the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9078676 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature