A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy.

ABSTRACT: To overcome the toxicity of chemotherapy, increasing attention has been paid to local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as promising DDS materials in the biomedical field due to their remarkable characteristics. However, the pH environment in tumor varies from person to person, which makes the applicability of systems based on pH challenging. In this study, we developed a contractible hydroxypropyl methyl cellulose (HPMC)/Fe₃O₄ hydrogel with dual-response pH and magnetic properties aiming to overcome the limitations of pH-sensitive hydrogel drug delivery systems and further increase their efficiency in tumor therapy. The HPMC/Fe₃O₄ hydrogel could act as a drug delivery system that combines pH-sensitive triggering a

SUBMITTER: Zhou X 

PROVIDER: S-EPMC9078710 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature