Identification and Validation of Inflammatory Response-Related Gene Signatures to Predict the Prognosis of Neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB) is the third most common malignant tumor in children. The inflammation is believed to be closely related to NB patients' prognosis. However, there is no comprehensive research to study the role of inflammatory response-related gene (IRRG) in NB patients.

Methods

We downloaded the gene expression profiles of NB patients from GEO and TARGET database, and the expression of 200 IRRGs was extracted. Then, we performed differentially analysis between INSS stage 4 and INSS stage 4S NB patients. The univariate and multivariate Cox regression analyses were performed to screen out the overall survival- (OS-) and event-free survival- (EFS-) related IRRGs in GSE49710, and two signatures were constructed; both signatures were evaluated by Kaplan-Meier (K-M)

SUBMITTER: Song J 

PROVIDER: S-EPMC9078807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature