A correlation study of biological activity and molecular docking of Asp and Glu linked bis-hydrazones of quinazolinones.

ABSTRACT: The present investigation involves the synthesis and spectroscopic and biological activity studies of the bis-hydrazones of quinazolinones derived from aspartic acid and glutamic acid. The antioxidant activities of the compounds were evaluated using DPPH, DMPD and ABTS radical scavenging assays whose results revealed that the IC₅₀ of compounds 6, 7, 11, 12, 20, 21, 25 and 26 was lower than those of the standard references. The anti-inflammatory activity was evaluated with a haemolysis assay using a human blood erythrocytes suspension and the results demonstrated that compounds 8, 9, 13, 14, 22, 23, 27 and 28 were excellent anti-inflammatory agents. In addition, the antibacterial and antifungal activities against various clinical pathogens of human origin revealed that compounds

SUBMITTER: Kumara HK 

PROVIDER: S-EPMC9078910 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature