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Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes.

ABSTRACT: Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

SUBMITTER: Mohamed HA

PROVIDER: S-EPMC9078921 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes.

Mohamed H A HA Khuphe M M Boardman S J SJ Shepherd S S Phillips R M RM Thornton P D PD Willans C E CE

RSC advances 20180315 19

Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned. ...[more]

PMID: 35540495

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