A structural dissection of protein-RNA interactions based on different RNA base areas of interfaces.

ABSTRACT: Protein-RNA interactions are very common cellular processes, but the mechanisms of interactions are not fully understood, mainly due to the complicated RNA structures. By the elaborate investigation on RNA structures of protein-RNA complexes, it was firstly found in this paper that RNAs in these complexes could be clearly classified into three classes (high, medium and low) based on the different levels of P _base (the percentage of base area buried in the RNA interface). In view of the three RNA classes, more detailed analyses on protein-RNA interactions were comprehensively performed from various aspects, including interface area, structure, composition and interaction force, so as to achieve a deeper understanding of the recognition specificity for the three classes of

SUBMITTER: Hu W 

PROVIDER: S-EPMC9078961 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature