Cross-dehydrogenative coupling of coumarins with Csp³-H bonds using an iron-organic framework as a productive heterogeneous catalyst.

ABSTRACT: The iron-organic framework VNU-20 was utilized as an active heterogeneous catalyst for the cross-dehydrogenative coupling of coumarins with Csp³-H bonds in alkylbenzenes, cyclohexanes, ethers, and formamides. The combination of DTBP as the oxidant and DABCO as the additive led to high yields of coumarin derivatives. The VNU-20 was more active towards this reaction than numerous other homogeneous and heterogeneous catalysts. Heterogeneous catalysis was confirmed for the cross-dehydrogenative coupling transformation utilizing the VNU-20 catalyst, and the contribution of active iron species in the liquid phase was insignificant. The iron-based framework was reutilized many times for the functionalization of coumarins without a remarkable decline in catalytic efficiency. To the best of our knowledge, these reactions of coumarins have not previously been conducted using heterogeneous catalysts.

SUBMITTER: Doan SH 

PROVIDER: S-EPMC9078982 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature