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Toxin-antitoxin systems in pathogenic Vibrio species: a mini review from a structure perspective.

ABSTRACT: Toxin-antitoxin (TA) genetic modules have been found to widely exist in bacterial chromosomes and mobile genetic elements. They are composed of stable toxins and less stable antitoxins that can counteract the toxicity of toxins. The interactions between toxins and antitoxins could play critical roles in the virulence and persistence of pathogenic bacteria. There are at least eight types of TA systems which have been identified in a variety of bacteria. Vibrio, a genus of Gram-negative bacteria, is widespread in aquatic environments and can cause various human diseases, such as epidemic cholera. In this review, we mainly explore the structures and functions of TA modules found in common Vibrio pathogens, mainly V. cholerae, for better understanding of TA action mechanisms in pathogenic bacteria.

SUBMITTER: Song X

PROVIDER: S-EPMC9079197 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Toxin-antitoxin systems in pathogenic <i>Vibrio</i> species: a mini review from a structure perspective.

Song Xiaojie X Lin Zhi Z Yuan Wensu W

3 Biotech 20220507 6

Toxin-antitoxin (TA) genetic modules have been found to widely exist in bacterial chromosomes and mobile genetic elements. They are composed of stable toxins and less stable antitoxins that can counteract the toxicity of toxins. The interactions between toxins and antitoxins could play critical roles in the virulence and persistence of pathogenic bacteria. There are at least eight types of TA systems which have been identified in a variety of bacteria. <i>Vibrio</i>, a genus of Gram-negative bac ...[more]

PMID: 35542053

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Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.

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