Descemet membrane endothelial keratoplasty in eyes with COL8A2-associated corneal dystrophy.

ABSTRACT:

Purpose

The p.(Leu450Trp) COL8A2 mutation, associated with an early-onset corneal endothelial dystrophy, can result in bullous keratopathy within the first few decades of life. People with this condition frequently experience anterior corneal changes in keratometry as the disease worsens, which may potentially affect refractive error after endothelial keratoplasty. We describe outcomes of the first cases of Descemet Membrane Endothelial Keratoplasty (DMEK) for patients with known mutations in this gene.

Observations

Four eyes from two patients with COL8A2-associated corneal dystrophy underwent DMEK for this condition at a tertiary academic center. Preoperative and postoperative Scheimpflug imaging and manifest refraction was conducted. Mean central corneal thic

SUBMITTER: Dzhaber D 

PROVIDER: S-EPMC9079234 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature