PtO₂/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups.

ABSTRACT: A highly efficient PtO₂/PTSA catalyst system for the hydration of a wide array of alkynes was developed. This method proved to be compatible with a large range of functional groups and the ketone products were obtained in high yields. The scope of this methodology was also extended to the synthesis of 3-aryl-isochromenones, -indoles and -benzofurans.

SUBMITTER: Lin HP 

PROVIDER: S-EPMC9079276 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature