Molecular characterization of chronic liver disease dynamics: From liver fibrosis to acute-on-chronic liver failure.

ABSTRACT:

Background & aims

The molecular mechanisms driving the progression from early-chronic liver disease (CLD) to cirrhosis and, finally, acute-on-chronic liver failure (ACLF) are largely unknown. Our aim was to develop a protein network-based approach to investigate molecular pathways driving progression from early-CLD to ACLF.

Methods

Transcriptome analysis was performed on liver biopsies from patients at different liver disease stages, including fibrosis, compensated cirrhosis, decompensated cirrhosis and ACLF, and control healthy livers. We created 9 liver-specific disease-related protein-protein interaction networks capturing key pathophysiological processes potentially related to CLD. We used these networks as a framework and performed gene set-enrichment analysis (GSEA) to

SUBMITTER: Graupera I 

PROVIDER: S-EPMC9079303 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature