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Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation.

ABSTRACT: Exposure to UV radiation may cause harmful effects to the skin such as damage, aging and cancer, which can be prevented by using sunscreens. Here, two azobenzene derivatives, 4-cholesterocarbonyl-4'-(N,N,N-triethylaminebutyloxyl bromide) azobenzene (CAB) and 4-cholesterocarbonyl-4'-(N,N-diethylaminebutyloxyl) azobenzene (ACB) were studied as reusable sunscreen candidates. Biocompatibility studies including apoptosis, cytotoxicity and in vivo phototoxicity revealed that the two compounds were rather safe, except ACB, which showed a weak phototoxicity in vitro. Both CAB and ACB have good UV absorption capacity not only in their solution state (dimethylsulfoxide, DMSO) but also in the cosmetic cream state. A commercial sunscreen, avobenzone was decomposed upon UV irradiation and lost its UV protection ability, while that of CAB and ACB could be quickly recovered upon visible light irradiation, implying that they can serve as a new type of reusable sunscreen.

SUBMITTER: Liu JL

PROVIDER: S-EPMC9079677 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation.

Liu Jiao-Li JL Wada Satoshi S Wang Jin-Ye JY

RSC advances 20180410 24

Exposure to UV radiation may cause harmful effects to the skin such as damage, aging and cancer, which can be prevented by using sunscreens. Here, two azobenzene derivatives, 4-cholesterocarbonyl-4'-(N,N,N-triethylaminebutyloxyl bromide) azobenzene (CAB) and 4-cholesterocarbonyl-4'-(N,N-diethylaminebutyloxyl) azobenzene (ACB) were studied as reusable sunscreen candidates. Biocompatibility studies including apoptosis, cytotoxicity and in vivo phototoxicit ...[more]

PMID: 35542531

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Project description:BackgroundPhotography using a UV transmitting filter allows UV light to pass and can be used to illuminate UV blocking lotions such as sunscreens.ObjectiveThe aim of this study is to compare currently available UV photography cameras and assess whether these devices can be used as visualization tools for adequate coverage of sun protection lotions.MethodsThis study was conducted in 3 parts: in phase 1, 3 different UV cameras were tested; in phase 2, we explored whether UV photography could work on a range of sun protection products; and in phase 3, a UV webcam was developed and was field-tested in a beach setting. In phase 1, volunteers were recruited, and researchers applied 3 sun protection products (ranging from sun protection factor [SPF] 15 to 50+) to the participants' faces and arms. UV photography was performed using 3 UV cameras, and the subsequent images were compared. In phase 2, volunteers were recruited and asked to apply their own SPF products to their faces in their usual manner. UV photographs were collected in the morning and afternoon to assess whether the coverage remained over time. Qualitative interviews were conducted to assess the participants' level of satisfaction with the UV image. In phase 3, a small portable UV webcam was designed using a plug-and-play approach to enable the viewing of UV images on a larger screen. The developed webcam was deployed at a public beach setting for use by the public for 7 days.ResultsThe 3 UV camera systems tested during phase 1 identified the application of a range of sun protection lotions of SPF 15 to 50+. The sensitivity of the UV camera devices was shown to be adequate, with SPF-containing products applied at concentrations of 2 and 1 mg/cm2 clearly visible and SPF-containing products applied at a concentration of 0.4 mg/cm2 having lower levels of coverage. Participants in phase 2 reported high satisfaction with the UV photography images, with 83% (29/35) of participants likely to use UV photography in the future. During phase 2, it was noted that many participants used tinted SPF-containing cosmetics, and several tinted products were further tested. However, it was observed that UV photography could not identify the areas missed for all tinted products. During phase 3, the electrical components of the UV webcam remained operational, and the camera was used 233 times by the public during field-testing.ConclusionsIn this study, we found that UV photography could identify the areas missed by sun protection lotions with chemical filters, and participants were engaged with personalized feedback.Trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12619000975190; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377089 ; Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12619000145101; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376672.

Dataset Information

Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation.

Publications

Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation.

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