Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems.

ABSTRACT: The delivery of drugs to the bloodstream via oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets (e.g. peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fol

SUBMITTER: Hobson JJ 

PROVIDER: S-EPMC9079742 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature