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A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A.

ABSTRACT: Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities.

SUBMITTER: Xu J

PROVIDER: S-EPMC9079787 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A.

Xu Jingjing J Wang Kai K Wu Jinlong J

RSC advances 20180412 25

Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available <i>p</i>-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities. ...[more]

PMID: 35539328

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