Daily running enhances molecular and physiological circadian rhythms in skeletal muscle.

ABSTRACT:

Objective

Exercise is a critical component of a healthy lifestyle and a key strategy for the prevention and management of metabolic disease. Identifying molecular mechanisms underlying adaptation in response to chronic physical activity is of critical interest in metabolic physiology. Circadian rhythms broadly modulate metabolism, including muscle substrate utilization and exercise capacity. Here, we define the molecular and physiological changes induced across the daily cycle by voluntary low intensity daily exercise.

Methods

Wildtype C57BL6/J male and female mice were housed with or without access to a running wheel for six weeks. Maximum running speed was measured at four different zeitgeber times (ZTs, hours after lights on) using either electrical or manual stimulation

SUBMITTER: Casanova-Vallve N 

PROVIDER: S-EPMC9079800 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature