Self-assembly of amphiphilic truncated cones to form hollow nanovesicles.

ABSTRACT: To mimic the unique properties of capsid (protein shell of a virus), we performed Brownian dynamics simulations of the self-assembly of amphiphilic truncated cone particles with anisotropic interactions. The particle shape of a truncated cone in our simulations depended on the cone angle θ, truncated height h _c and particle type (A _x B _y and B _x A _y B _z ). The hydrophobic A moieties and hydrophilic B moieties are responsible for attractive and repulsive interactions, respectively. By varying the particle shape, truncated cones can assemble into hollow and vesicle-like clusters with a specific cluster size N. To assemble into hollow vesicles, the truncated height h

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9079828 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature