Dual-sensitive chitosan derivative micelles for site-specific drug release in the treatment of chicken coccidiosis.

ABSTRACT: Coccidiosis is a widespread and economic disease that deteriorates the growth of infected animals and largely affects our food safety. It has been proved that chitosan and its derivatives could offer outstanding antibacterial and hemostatic capabilities and help increase weight gain in the breeding of poultry. Herein, we put forward a novel strategy for the development of anti-coccidiosis drug formulations, aiming to synthesize 3-carboxyphenylboronic acid (CPBA) modified chitosan (CS) conjugates which could be self-assembled into polymeric micelles together with diclazuril (DIC), a poorly water-soluble coccidiostat drug, for site-specific drug release in the treatment of animal coccidiosis. The CPBA-modified micelles possessed specific glucose and pH dual-responsive capacity. The cumulativ

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9079931 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature