Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques.
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ABSTRACT:
SUBMITTER: Zheng H
PROVIDER: S-EPMC9080054 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques.
Zheng Huiwen H Chen Yanli Y Li Jing J Li Heng H Zhao Xin X Li Jiali J Yang Fengmei F Li Yanyan Y Liu Changkun C Qin Li L Zuo Yuanyuan Y Zhang Qian Q He Zhanlong Z Shi Haijing H Li Qihan Q Liu Longding L
Cell reports 20220508 8
The pathological and immune response of individuals with COVID-19 display different dynamics in lung and intestine. Here, we depict the single-cell transcriptional atlas of longitudinally collected lung and intestinal tissue samples from SARS-CoV-2-infected monkeys at 3 to 10 dpi. We find that intestinal enterocytes are degraded at 3 days post-infection but recovered rapidly, revealing that infection has mild effects on the intestine. Crucially, we observe suppression of the inflammatory respons ...[more]
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