Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl₄ induced acute liver injury in mice.

ABSTRACT: Excessive accumulation of free radicals in the body can cause liver damage, aging, cancer, stroke, and myocardial infarction. Anastatin B, a skeletal flavonoid, was reported to have antioxidant and hepatoprotective effects. Anastatin B derivatives, compound 1 and 2, were synthesized by our group previously. In this study, their antioxidant activity and hepatoprotective mechanism were studied using chemical evaluation methods, a cellular model of hydrogen peroxide (H₂O₂)-induced oxidative damage, and a mouse model of carbon tetrachloride (CCl₄)-induced liver injury. Results from the chemical evaluation suggested that both compounds had good antioxidant power and radical scavenging ability in vitro. MTT assay showed that both compounds had cytoprotecti

SUBMITTER: Xiang C 

PROVIDER: S-EPMC9080091 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature