Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil.

ABSTRACT:

Background

Over a third of the world's population is at risk of Plasmodium vivax-induced malaria. The unique aspect of the parasite's biology and interactions with the human host make it harder to control and eliminate the disease. Glucose-6-phosphate dehydrogenase (G6PD) deficiency and Duffy-negative blood groups are two red blood cell (RBC) variations that can confer protection against malaria.

Methods

Molecular genotyping of G6PD and Duffy variants was performed in 225 unrelated patients (97 with uncomplicated and 128 with severe vivax malaria) recruited at a Reference Centre for Infectious Diseases in Manaus. G6PD and Duffy variants characterizations were performed using Real Time PCR (qPCR) and PCR-RFLP, respectively.

Results

The Duffy blood group system showed a

SUBMITTER: Ferreira NS 

PROVIDER: S-EPMC9080172 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature