Identification of novel key regulatory lncRNAs in gastric adenocarcinoma.

ABSTRACT:

Background

Stomach adenocarcinoma (STAD) is one of the most common and deadly cancers worldwide. Recent evidence has demonstrated that dysregulation of long noncoding RNAs (lncRNA) is associated with different hallmarks of cancer. lncRNAs also were suggested as novel promising biomarkers for cancer diagnosis and prognosis. Despite these previous investigations, the expression pattern, diagnostic role, and hallmark association of lncRNAs in STAD remain unclear.

Results

In this study, The STAD lncRNA-mRNA network was constructed based on RNAs that differentially expressed among tumor and normal samples and had a strong expression correlation with others. The high degree nodes of the network were associated with overall survival. In addition, we found that the hubs' regulatory

SUBMITTER: Razavi H 

PROVIDER: S-EPMC9080188 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature