Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells.

ABSTRACT: The structure of novel binary nanosponges consisting of (cholesterol-(K/D) _n DEVDGC)₃-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)₂₀ or aspartic acid (D)₂₀ are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Furthermore, the binary (DK20) nanosponges have been found to be virtually non-toxic in cultures of neural progenitor cells. It is of a special importance for the future development

SUBMITTER: Yapa AS 

PROVIDER: S-EPMC9080234 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature