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Copper-catalyzed C-H acyloxylation of 2-phenylpyridine using oxygen as the oxidant.

ABSTRACT: An efficient copper-catalyzed direct o-acyloxylation of 2-phenylpyridine with carboxylic acids using oxygen as the oxidant has been developed. Various acids including aromatic acids, cinnamic acids and aliphatic acids are effective acyloxylation reagents and provide the desired products in moderate to excellent yields. The reaction proceeds well under an oxygen atmosphere, making this method potentially practical.

SUBMITTER: Wang F

PROVIDER: S-EPMC9080246 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Copper-catalyzed C-H acyloxylation of 2-phenylpyridine using oxygen as the oxidant.

Wang Feifan F Lin Zhiyang Z Yu Weisheng W Hu Qingdong Q Shu Chao C Zhang Wu W

RSC advances 20180401 29

An efficient copper-catalyzed direct o-acyloxylation of 2-phenylpyridine with carboxylic acids using oxygen as the oxidant has been developed. Various acids including aromatic acids, cinnamic acids and aliphatic acids are effective acyloxylation reagents and provide the desired products in moderate to excellent yields. The reaction proceeds well under an oxygen atmosphere, making this method potentially practical. ...[more]

PMID: 35542218

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