MC4R variant rs17782313 and manifestation of obese phenotype in Pakistani females.

ABSTRACT: MC4R represents a key player involved in melanocortin-mediated control of energy balance. Recently identified near MC4R variant rs17782313 (T > C) can serve as a contributing factor for obese phenotype but its association with obesity has never been sought in a sample of the Pakistani population. The role of genetic variants as causal factors varies across populations. Association studies in a specific population can help us to distinguish global from local gene-gene and gene-environment interactions. This is the first study that investigated the association of rs17782313 with obesity and various obesity-linked anthropometric, metabolic, physical, and behavioural traits in Pakistani subjects including 306 OW/OB (overweight and obese) and 300 NW (normal weight) individuals. The comparison o

SUBMITTER: Rana S 

PROVIDER: S-EPMC9080305 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature