Effect of Rhizoma Paridis saponin on the pain behavior in a mouse model of cancer pain.

ABSTRACT: Rhizoma Paridis saponins (RPS) as active parts of P. polyphylla Smith var. yunnanensis has been used as an anti-cancer drug in traditional Chinese medicine. In this study, RPS was first found to demonstrate a potent effect on markedly reducing the pain induced by cancer. Therefore, the aim of this study was to further explore the analgesic effect of RPS and its possible reaction pathway on H22 hepatocarcinoma cells inoculated in the hind right paw of mice. Cancer-induced pain model mice were randomly divided into 5 groups (n = 10) and orally administered with RPS (50-200 mg kg^-1) for 2 weeks. On the last day of treatment, the pain behavior of mice was measured using hot-plate test and open field test, and brain tissues were sampled for detection of biochemic

SUBMITTER: Wang G 

PROVIDER: S-EPMC9080318 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature