Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest.

ABSTRACT: A series of six new bis(thiosemicarbazone)copper(i) complexes of the type [Cu(L^1-6)₂Cl] (1-6) have been synthesized and characterized. The molecular structure of the ligand L⁴ was determined by the single crystal XRD method. All the complexes adopted trigonal planar (Y-shaped) geometry. All the complexes strongly bind with CT-DNA via intercalative mode, which was further supported by molecular docking studies. Further, the complexes were effectively bind with BSA as observed by UV-Vis and fluorescence spectra. All the complexes effectively cleave pBR322 DNA through hydrolytic pathway as evidenced from T4 ligase experiments. All the complexes interact with the anticancer receptor focal adhesion kinase (FAK) via electrostatic, van der Waals, hyd

SUBMITTER: Mahendiran D 

PROVIDER: S-EPMC9080330 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature