The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma.

ABSTRACT:

Objective

MicroRNAs (miRNAs) are key post-transcriptional regulators of protein translation in humans. They have an essential role in various cancers, including nasopharyngeal carcinoma (NPC). The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets. This study provides a systematic view of the roles of miR-21 and its network of targets (hsa-miR-21-3p, hsa-miR-21-5p) that are associated with nasopharyngeal carcinoma.

Methods

Bioinformatics tools were applied to predict the targets of miR-21. Interactions among the targets of hsa-miR-21-3p/5p were found by the gene MANIA online tool.

Results and conclusion

It was found that the target genes are involved in vital biological processes in cancer.

SUBMITTER: Lao TD 

PROVIDER: S-EPMC9080362 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature