Chloramphenicol-borate/boronate complex for controlling infections by chloramphenicol-resistant bacteria.

ABSTRACT: Increasing bacterial resistance to antibiotics is a pressing problem worldwide, with many health organisations prioritizing this issue. Whilst there is a desperate need for new effective antimicrobials, it is also important to understand the mechanisms and epidemiology of the resistant pathogens currently present in the community. Chloramphenicol is one such well known antibiotic which had lost its efficacy due to bacterial resistance. In this paper, we report the design, synthesis, and bio-studies of novel chloramphenicol-borate/boronate derivatives which showed the ability to control the infections caused by chloramphenicol-resistant bacteria. Activity profiling against P. aeruginosa strain EXR1 with catB gene indicated the inability of acetyl transferase to acetylate the c

SUBMITTER: Bhattacharya P 

PROVIDER: S-EPMC9080503 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature