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Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy.

ABSTRACT: We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.

SUBMITTER: Hwang BW

PROVIDER: S-EPMC9080606 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy.

Hwang Byung Woo BW Kim Young-Eun YE Kim Mungu M Han Seulgi S Bok Seoyeon S Park Kyeng Min KM Shrinidhi Annadka A Kim Ki Su KS Ahn G-One GO Hahn Sei Kwang SK

RSC advances 20180522 34

We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. <i>In vivo</i> angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion. ...[more]

PMID: 35539688

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