A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition.

ABSTRACT: A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF₂H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF₂H group.

SUBMITTER: Yu X 

PROVIDER: S-EPMC9080679 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature