Dataset Information

Mussel-inspired bio-compatible free-standing adhesive films assembled layer-by-layer with water-resistance.

ABSTRACT: The development of mussel-inspired materials with enhanced mechanical and physiological characteristics is fascinating due to the resulting structural properties. In this work, based on a chemical reaction, 3-(3,4-dihydroxyphenyl)propionic acid and dopamine hydrochloride (DA), with a catechol group, were covalently grafted onto a bio-compatible polymer backbone of chitosan hydrochloride (CHI) and hyaluronic acid sodium (HA). A mussel-inspired water-resistant adhesive film that could adhere in water was then fabricated by an environmentally friendly layer-by-layer (LbL) process. The water-resistant adhesive film demonstrated a strong underwater mechanical connection (0.82 ± 0.19 MPa) and a high transmittance (more than 83%) in the visible region; these characteristics are beneficial for clinical observation. A free-standing water-resistant adhesive film with a high transmittance of over 83% was also demonstrated and obtained from a facial and effective mechanical exfoliation method. The free-standing film exhibited favorable adhesion capacity with porcine skin, making it attractive for applications in the biomedical field.

SUBMITTER: Wang D

PROVIDER: S-EPMC9080690 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Mussel-inspired bio-compatible free-standing adhesive films assembled layer-by-layer with water-resistance.

Wang Dan D Zhang Jianfu J Zhong Yingjie Y Chu Ming M Chang Wenyang W Yao Zhanhai Z

RSC advances 20180522 34

The development of mussel-inspired materials with enhanced mechanical and physiological characteristics is fascinating due to the resulting structural properties. In this work, based on a chemical reaction, 3-(3,4-dihydroxyphenyl)propionic acid and dopamine hydrochloride (DA), with a catechol group, were covalently grafted onto a bio-compatible polymer backbone of chitosan hydrochloride (CHI) and hyaluronic acid sodium (HA). A mussel-inspired water-resistant adhesive film that could adhere in wa ...[more]

PMID: 35539663

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Project description:The combination of multiple physiological (swelling, porosity, mechanical, and biodegradation) and biological (cell/tissue-adhesive, cell proliferation, and hemostatic) properties on a single hydrogel has great potential for skin tissue engineering. Adhesive hydrogels based on polydopamine (PDA) have become the most popular in the biomedical field; however, integrating multiple properties on a single adhesive hydrogel remains a challenge. Here, inspired by the chemistry of mussels, we developed PDA-sodium alginate-polyacrylamide (PDA-SA-PAM)-based hydrogels with multiple physiological and biological properties for skin tissue engineering applications. The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. The chemical composition of the hydrogels was characterized by X-ray photoelectron spectroscopy. PDA-SA complexed chains were homogeneously dispersed in the PAM network and exhibited good elasticity and excellent mechanical properties, such as a compressive stress of 0.24 MPa at a compression strain of 70% for 0.4PDA-SA-PAM. The adhesive hydrogel also maintained a highly interconnected porous structure (∼94% porosity) along with PDA microfibrils. The hydrogel possesses outstanding swelling and biodegradability properties. Owing to the presence of the PDA-SA complex in the PAM network, the hydrogels show good adhesion to various substrates (plastic, skin, glass, computer screens, and leaves); for example, the adhesive strength of the 0.4PDA-SA-PAM to porcine skin was 24.5 kPa. The adhesive component of the PDA-SA chains in the PAM network significantly improves the cell proliferation, cell attachment, cell spreading, and functional expression of human skin fibroblasts (CCD-986sk) and keratinocytes. Moreover, the PDA chains exhibited good hemostatic properties, resulting in rapid blood coagulation. Considering their excellent cell affinity, and rapid blood coagulation ability, these mussel-inspired hydrogels have substantial potential for skin tissue engineering applications.

Dataset Information

Mussel-inspired bio-compatible free-standing adhesive films assembled layer-by-layer with water-resistance.

Publications

Mussel-inspired bio-compatible free-standing adhesive films assembled layer-by-layer with water-resistance.

Similar Datasets

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