A novel amphiphilic fluorescent probe BODIPY-O-CMC-cRGD as a biomarker and nanoparticle vector.

ABSTRACT: Fluorescent probes have been demonstrated to be promising candidates as biomarkers and biological carriers. Our study focuses on the development of a novel amphiphilic fluorescent probe with good photostability, high water solubility, excellent specificity and promising loading capability for tumor diagnosis and treatment. At first, BODIPY dye and O-carboxymethyl chitosan were prepared via a chemical reaction. Then, the prepared BODIPY dye and cRGD were bonded to O-carboxymethyl chitosan successively via an acylation reaction. Finally, we obtained the desired amphiphilic fluorescent probe: BODIPY-O-CMC-cRGD, which was based on the fluorescence resonance energy transfer (FRET) principle for selective visualization of tumors in vitro. Through a serie

SUBMITTER: Zhu T 

PROVIDER: S-EPMC9080774 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature