Entry and passage behavior of biological cells in a constricted compliant microchannel.

ABSTRACT: We report an experimental and theoretical investigation of the entry and passage behaviour of biological cells (HeLa and MDA-MB-231) in a constricted compliant microchannel. Entry of a cell into a micro-constriction takes place in three successive regimes: protrusion and contact (cell protrudes its leading edge and makes a contact with the channel wall), squeeze (cell deforms to enter into the constriction) and release (cell starts moving forward). While the protrusion and contact regime is insensitive to the flexibility of the channel, the squeeze zone is significantly smaller in the case of a more compliant channel. Similarly, in the release zone, the acceleration of the cells into the microconstriction is higher in the case of a more compliant channel. The results showed that for a fixe

SUBMITTER: Raj A 

PROVIDER: S-EPMC9080859 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature