Cortical connectivity is embedded in resting state at columnar resolution.

ABSTRACT: Resting state (RS) fMRI is now widely used for gaining insight into the organization of brain networks. Functional connectivity (FC) inferred from RS-fMRI is typically at macroscale, which is too coarse for much of the detail in cortical architecture. Here, we examined whether imaging RS at higher contrast and resolution could reveal cortical connectivity with columnar granularity. In longitudinal experiments (~1.5 years) in squirrel monkeys, we partitioned sensorimotor cortex using dense microelectrode mapping and then recorded RS with intrinsic signal optical imaging (RS-ISOI, 20 µm/pixel). FC maps were benchmarked against microstimulation-evoked activation and traced anatomical connections. These direct comparisons showed high correspondence in connectivity patterns across methods. The

SUBMITTER: Card NS 

PROVIDER: S-EPMC9080903 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature