In silico functional and tumor suppressor role of hypothetical protein PCNXL2 with regulation of the Notch signaling pathway.

ABSTRACT: Since the last decade, various genome sequencing projects have led to the accumulation of an enormous set of genomic data; however, numerous protein-coding genes still need to be functionally characterized. These gene products are called "hypothetical proteins". The hypothetical protein pecanex-like protein 2 Homo sapiens (PCNXL2) is found to be mutated in colorectal carcinoma with microsatellite instability; therefore, annotation of the function of PCNXL2 in tumorigenesis is very important. In the present study, bioinformatics analysis of PCNXL2 was performed at the molecular level to assess its role in the progression of cancer for designing new anti-cancer drugs. The retrieved sequence of PCNXL2 was functionally and structurally characterized through the web tools Pfam, Batch CD

SUBMITTER: Naveed M 

PROVIDER: S-EPMC9080940 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature