Non-targeted metabolite profiling and specific targeted discrimination strategy for quality evaluation of Cortex Phellodendri from different varieties.

ABSTRACT: Cortex Phellodendri is derived from two species of Phellodendron amurense Rupr. and Phellodendron chinense Schneid. Traditionally, the two species are utilized interchangeably under the name of "huangbo" in the clinic because they are believed to share the same clinical efficacy. However, the chemical analysis in vitro couldn't directly reflect the pharmacological effects. Therefore, whether the constituents could be absorbed into the blood becomes the uppermost problem to account for the clinical efficacy differences of the two species. Therefore, a rapid and sensitive approach to differentiate the two species of Cortex Phellodendri based on non-targeted metabolite profiling and the specific targeted discrimination strategy was first established. Samples from differen

SUBMITTER: Zhu G 

PROVIDER: S-EPMC9081087 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature