Dual-stimuli-responsive TiO _x /DOX nanodrug system for lung cancer synergistic therapy.

ABSTRACT: Biological applications of nanosheets are rapidly increasing currently, which introduces new possibilities to improve the efficacy of cancer chemotherapy and radiotherapy. Herein, we designed and synthesized a novel nano-drug system, doxorubicin (DOX) loaded titanium peroxide (TiO _x ) nanosheets, toward the synergistic treatment of lung cancer. The precursor of TiO₂ nanosheets with high specific surface area was synthesized by a modified hydrothermal process using the polymer P123 as a soft template to control the shape. TiO _x nanosheets were obtained by oxidizing TiO₂ nanosheets with H₂O₂. The anti-cancer drug DOX was effectively loaded on the surface of TiO _x nanosheets. Generation of reacti

SUBMITTER: Dai Z 

PROVIDER: S-EPMC9081125 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature