Linking drug and food addiction via compulsive appetite.

ABSTRACT:

Background and purpose

'Food addiction' is the subject of intense public and research interest. However, this nosology based on neurobehavioural similarities among obese individuals, patients with eating disorders and those with substance use disorders (drug addiction) remains controversial. We thus sought to determine which aspects of disordered eating are causally linked to preclinical models of drug addiction. We hypothesized that extensive drug histories, known to cause addiction-like brain changes and drug motivation in rats, would also cause addiction-like food motivation.

Experimental approach

Rats underwent extensive cocaine, alcohol, caffeine or obesogenic diet histories and were subsequently tested for punishment-resistant food self-administration or 'compulsive ap

SUBMITTER: Laque A 

PROVIDER: S-EPMC9081129 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature