Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is well characterized by type 2 (T2) inflammation characterized by eosinophilia in Western countries. However, the presence and roles of neutrophils in T2 CRSwNP are poorly understood.

Objective

We sought to clarify accumulation and inflammatory roles of neutrophils in CRSwNP in a Western population.

Methods

Sinonasal tissues and nasal lavage fluids were obtained from control patients and patients with CRS, and neutrophil markers were determined by ELISA. The presence of neutrophils in tissue was determined by flow cytometry. The gene expression profiles in neutrophils were determined by RNA sequencing.

Results

A neutrophil marker elastase was selectively elevated in nasal polyp (NP) tissue, whe

SUBMITTER: Poposki JA 

PROVIDER: S-EPMC9081139 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature