Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.

ABSTRACT: It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

SUBMITTER: Mazzitelli JA 

PROVIDER: S-EPMC9081158 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature