Effectiveness and safety of intrauterine insemination vs. assisted reproductive technology: emulating a target trial using an observational database of administrative claims.

ABSTRACT:

Objective

To compare the effectiveness and safety of 1 cycle of assisted reproductive technology (ART) vs. 3 cycles of intrauterine insemination (IUI).

Design

Target trial emulation using observational data.

Setting

A healthcare claims database (2011-2015).

Patient(s)

The patients were 29,021 women aged 18-45 years with an infertility diagnosis and no history of IUI or ART within the past 12 months.

Intervention(s)

One ART cycle immediately, with no more cycles of ART or IUI within the next 4 months; or 1 IUI cycle immediately, with 2 additional consecutive cycles of IUI within the next 4 months unless pregnancy occurred.

Main outcome measure(s)

Live births, multiple births, congenital malformations, preterm births, small-for-gestational-age newbo

SUBMITTER: Chiu YH 

PROVIDER: S-EPMC9081198 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature