Antibody-pHPMA functionalised fluorescent silica nanoparticles for colorectal carcinoma targeting.

ABSTRACT: The systemic application of highly potent drugs such as cytostatics poses the risks of side effects, which could be reduced by using a carrier system able to specifically deliver the encapsulated drug to the target tissue. Essential components of a nanoparticle-based drug delivery system include the drug carrier itself, a targeting moiety, and a surface coating that minimizes recognition by the immune system. The present work reports on the preparation, in vitro characterization and in vivo testing of a new delivery system consisting of fluorescent silica nanoparticles functionalised with a non-immunogenic stealth polymer poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA) and a monoclonal antibody IgG M75 that specifically binds to Carbonic Anhydrase IX (CA IX). CA IX is

SUBMITTER: Lizonova D 

PROVIDER: S-EPMC9081219 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature