Association of infertility with atherosclerotic cardiovascular disease among postmenopausal participants in the Women's Health Initiative.

ABSTRACT:

Objective

To investigate the association of infertility with atherosclerotic cardiovascular disease (ASCVD) among postmenopausal participants in the Women's Health Initiative (WHI). We hypothesized that nulliparity and pregnancy loss may reveal more extreme phenotypes of infertility, enabling further understanding of the association of infertility with ASCVD.

Design

Prospective cohort study.

Setting

Forty clinical centers in the United States.

Patient(s)

A total of 158,787 postmenopausal participants in the Women's Health Initiative cohort.

Intervention(s)

Infertility, parity, and pregnancy loss.

Main outcome measure(s)

The primary outcome was risk of ASCVD among women with and without a history of infertility, stratified by history of live birth

SUBMITTER: Murugappan G 

PROVIDER: S-EPMC9081220 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature