Assessing Aedes aegypti candidate genes during viral infection and Wolbachia-mediated pathogen blocking.

ABSTRACT: One approach to control dengue virus transmission is the symbiont Wolbachia, which limits viral infection in mosquitoes. Despite plans for its widespread use in Aedes aegypti, Wolbachia's mode of action remains poorly understood. Many studies suggest that the mechanism is likely multifaceted, involving aspects of immunity, cellular stress and nutritional competition. A previous study from our group used artificial selection to identify a new mosquito candidate gene related to viral blocking; alpha-mannosidase-2a (alpha-Mann-2a) with a predicted role in protein glycosylation. Protein glycosylation pathways tend to be involved in complex host-viral interactions; however, the function of alpha-mannosidases has not been described in mosquito-virus interactions. We examined alpha-Mann-2a expres

SUBMITTER: Sigle LT 

PROVIDER: S-EPMC9081237 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature