Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC9081259 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20220420 17
The hexadehydro-Diels-Alder (HDDA) reaction converts a 1,3-diyne bearing a tethered alkyne (the diynophile) into bicyclic benzyne intermediates upon thermal activation. With only a few exceptions, this unimolecular cycloisomerization requires, depending on the nature of the atoms connecting the diyne and diynophile, reaction temperatures of <i>ca.</i> 80-130 °C to achieve a convenient half-life (<i>e.g.</i>, 1-10 h) for the reaction. In this report, we divulge a new variant of the HDDA process i ...[more]