Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer has a strong epigenetic component that is accompanied by frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of interest to understand the interrelationship of germline genetics, DNAm, and colorectal cancer risk.

Methods

We performed a genome-wide methylation quantitative trait locus (meQTL) analysis in 1,355 people, assessing the pairwise associations between genetic variants and lymphocytes methylation data. In addition, we used penalized regression with cis-genetic variants ± 1 Mb of methylation to identify genome-wide heritable DNAm. We evaluated the association of genetically predicted methylation with colorectal cancer risk based on genome-wide association studies (GWAS) of over 125,000 cases and control

SUBMITTER: Barfield R 

PROVIDER: S-EPMC9081265 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature