Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles.

ABSTRACT: NaGdF₄:Yb³⁺/Er³⁺ nanoparticles were synthesized via a modified hydrothermal route. The dependence of structure and morphology on the dosage of sodium polyacrylate was studied by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The as-prepared nanoparticles could be used for T ₂ weighted magnetic resonance imaging due to the paramagnetism of Gd³⁺. cis-dichlorodiamineplatinum (CDDP) could be loaded onto NaGdF₄:Yb³⁺/Er³⁺ nanoparticles through binding carboxyl in the form of Pt-O bonds, and doxorubicin (DOX) could be loaded via hydrogen bonding. DOX could also be loaded onto the NaGdF₄-CDDP composite in the same manner, and the loading efficiency of

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9081283 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature